LIPID PROFILE AND ESTRADIOL ANALYSIS BETWEEN PRE-MENOPAUSE AND POSTMENOPAUSE WOMEN IN MEDAN AREAS OF NORTH SUMATERA, INDONESIA

Journal of Chemical and Pharmaceutical Research, 2015, 7(10):505-508

Senin, 11 September 2017 09:58 | Sudah dibaca 458 kali

Analysis of lipid profile and hormone status between pre menopause and post menopause women was investigated. Subject that investigated in this study amounted to 120 people and classified by group of age namely group I (30-39 years old), group II (40-49 years old), group III (50-59 years old) and group IV (≥60 years old). The concentration of lipid profile in each age group which includes cholesterol, triglycerides were determined by colorimetric enzymatic method. Apolipoprotein determined by spectrophotometry method. Estradiol and FSH level were determined by RIA method. There are significant differences in estradiols level and FSH levels in groups II and III (P < 0,001).there was no significant differences in lipid profiles in the age group, except for HDL in group III and IV as well as triglycerides in group II and III. There are significant differences for apolipoprotein B in group I and II, also in group III and IV. the reducing of oestrogen production from ovaries results change in lipid profile, leads by reducing HDL and elevating total cholesterol, triglyceride, and LDL cholesterol, thus increasing the risk of cardiovascular disease and breast cancer. The measurement of Apo-B may have great values in particular some individuals at risk of developing coronary artery disease are found to have increased level of Apo-B but have the normal concentration of cholesterol

Kata Kunci: lipid profile, post menopause, pre menopause, estradiol