THE EFFECT OF ION CD(II) IN THE KIDNEY OF EXPERIMENTAL RATS AND UTILIZATION OF CASSAVA LEAVES (MANIHOT UTILISIMA) AS ANTIDOTE

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Senin, 11 September 2017 10:52 | Sudah dibaca 611 kali

The present study investigated the protective effect of Manihot utilissima leaves against cadmium induced oxidative stress in kidney of experimental rat. The administration intraperitoneally of cadmium lead to elevated levels of cadmium content in almost organs in mice except in brain. Administration of cadmium also increase some biochemical parameters and enzymes in serum include malondialdehyde, urea, creatinine, SGOT and SGPT. Pre oral treatment of Manihot utilissima leaves antidote could reduce the level of cadmium in all affected organs and biochemical parameters significantly. pre treatment with antidote could reduce the level of MDA,creatinine, urea, SGPT and SGOT to 52,8%, 30,3%, 15,2%, 64,3%, and 78,8% respectively compared with the cadmium induced rats group.From these result it can be concluded that antidote of Manihot utilissima leaves give preventive effect against cadmium toxicity.

Kata Kunci: Manihot utilissima, antidote, cadmium, oxidative stress