PROTECTIVE EFFECT OF AQUEOUS EXTRACT OF ANNONA MURICATA LEAVES AGAINST COPPER INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Senin, 11 September 2017 11:04 | Sudah dibaca 438 kali

This present study investigated the protective effect of A.muricata leaves antidote against Cu(II) induced toxicity in experimental rats. Administration of Cu(II) (1000 mg/L) intraperitoneally in experimental rats lead to the increasing of liver and kidney function parameters and oxidative stress parameters including SGOT, SGPT, urea, creatinine and malondialdehyde (MDA). Histological analysis of liver tissue indicate that administration of Cu(II) resulted in central vein dilation, swelling of hepatocytes and necrosis. Pre treatment with A.muricata leaves antidote significantly reduced the levels of liver and kidney function parameters and oxidative stress in rats. Decreased levels of SGOT, SGPT, urea, creatinine and MDA were 23,64%, 63,51%, 27,12, 44,37% respectively, compared with rats that were administered with Cu(II) alone. Histologically, pre treatment with A.muricata leaves antidote is able to reduce the effects of damage to the liver structure due to toxicity of Cu(II)

Kata Kunci: Annona muricata, Cu(II), oxidative stress, antidote