Protective Effect of Sauropus androgynus (L) Merr against Toxicity of Copper Induced Oxidative Stress and Ovary Damage in Experimental Rats

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Senin, 11 September 2017 11:16 | Sudah dibaca 511 kali

The present study was investigated the protective effect of antidote S.androgynus L Merr in experimental rats which exposed by Cu(II). The administration of Cu(II) intraperitoneally lead to increase level of serum biochemical parameters including SGOT, SGPT, urea, creatinine and malondialdehyde (MDA) significantly. The pre treatment with antidote S.androgynus L Merr before exposure with Cu(II) could reduced the elevated level of the SGOT, SGPT, urea, creatinine and MDA as 16,11%; 64,38%; 28,51%; 50% and 38,7% respectively. Histopathological analysis of ovary tissue indicate that pre treatment with S.androgynus L Merr able to reduce the severity of tissue damage in the ovary which indicate that antidote of S.androgynus L Merr give protective effect against Cu(II) toxicacy

Kata Kunci: Sauropus androgynus L Merr, Cu(II), oxidative stress, ovary