Research Journal of Pharmaceutical, Biological and Chemical Sciences

Senin, 11 September 2017 11:26 | Sudah dibaca 899 kali

The Virgin Coconut Oil (VCO) products have different qualities and controversy effects of lipids metabolism. This research used VCO from Padang Pariaman West Sumatra Indonesia, rich in Lauric acids. The procesing of VCO by naturally fermentation method, without adding chemicals. It has high amount of lauric acid (C12) up to 58 %, caprilic acid (C8) 8.9 %, capric acid (C10) 7.8 % included, vitamins A, D, E, K. This research aim to investigate some debate of using VCO in related to image that using Coconut Oil is bad for lipid pofile. This eperiment using dietary VCO as food supplement to determined lipid profile using 40 mice of Mus musculus, which divided into 4 groups. Feeding on egg yolk to Group I (negative control), Group II (positive control). The others were Group III fed with (egg yolk and VCO 2 %) and group IV (egg yolk and VCO 4 %). It was determined in plasma lipid profile, the total of cholesterol, High Density Lipoprotein (HDL). The duration time was 10, 20 and 30 days after treated analysed by using the enzymatic methods. The dietary of VCO 2 to 4% resulted in significant increases in HDL levels from 32 % to 69 %. The dietary of VCO 4 % for four weeks did not toxic to mice metabolism. Triglycerides level decreased from 177 mg/dL to 85 mg/dL, and similar resulted to cholesterol ratio. Feeding on VCO for 4 weeks, the (C10) SCFA and (C12) MCT not detected in plasma serum of mice. The LCFA (C16) palmitate is decreased from 0.96 mg/mL to 0.1 mg/mL.

Kata Kunci: virgin coconut oil, HDL, triglyceride, MCT metabolism, Mus musculus

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